Muscle injury promotes heterotopic ossification by stimulating local bone morphogenetic protein-7 production.

ABSTRACT:

Background

Heterotopic ossification (HO) is a pathological condition of abnormal bone formation in soft tissue, which causes pain and restricted range of motion in patients. There are two broad categories of HO, hereditary and acquired. Although different types of HO do not use identical mechanistic pathways of pathogenesis, muscle injury appears to be a unifying feature for all types of HO. However, little is known about the mechanisms by which muscle injury facilitates HO formation.

Objective and method

This study aimed to explore the cellular and molecular mechanisms linking muscle injury to HO by using cardiotoxin to induce muscle injury in a bone morphogenetic protein-2 (BMP-2)-induced HO mouse model.

Results

We found that muscle injury augmented HO formation and

SUBMITTER: Li 

PROVIDER: S-EPMC6718974 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature