Molecular Imaging Probes Based on Matrix Metalloproteinase Inhibitors (MMPIs).

ABSTRACT: Matrix metalloproteinases (MMPs) are a family of zinc- and calcium-dependent endopeptidases which are secreted or anchored in the cell membrane and are capable of degrading the multiple components of the extracellular matrix (ECM). MMPs are frequently overexpressed or highly activated in numerous human diseases. Owing to the important role of MMPs in human diseases, many MMP inhibitors (MMPIs) have been developed as novel therapeutics, and some of them have entered clinical trials. However, so far, only one MMPI (doxycycline) has been approved by the FDA. Therefore, the evaluation of the activity of a specific subset of MMPs in human diseases using clinically relevant imaging techniques would be a powerful tool for the early diagnosis and assessment of the efficacy of therapy. In recent ye

SUBMITTER: Rangasamy L 

PROVIDER: S-EPMC6719134 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature