Non-invasive assessment of glioma microstructure using VERDICT MRI: correlation with histology.

ABSTRACT:

Purpose

This prospective study evaluated the use of vascular, extracellular and restricted diffusion for cytometry in tumours (VERDICT) MRI to investigate the tissue microstructure in glioma. VERDICT-derived parameters were correlated with both histological features and tumour subtype and were also used to explore the peritumoural region.

Methods

Fourteen consecutive treatment-naïve patients (43.5 years ± 15.1 years, six males, eight females) with suspected glioma underwent diffusion-weighted imaging including VERDICT modelling. Tumour cell radius and intracellular and combined extracellular/vascular volumes were estimated using a framework based on linearisation and convex optimisation. An experienced neuroradiologist outlined the peritumoural oedema, enhancing tumour and n

SUBMITTER: Zaccagna F 

PROVIDER: S-EPMC6719328 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature