Prospective assessment of fibrinolysis in morbid obesity: tissue plasminogen activator resistance improves after bariatric surgery.

ABSTRACT:

Background

Morbid obesity is associated with an increased risk of thrombotic events, which has been attributed to increased thrombotic activity. Multiple mechanisms have been proposed to explain this increased risk, including an inflammatory state with upregulation of procoagulant and antifibrinolytic proteins. We therefore hypothesize that patients with morbid obesity are hypercoagulable and will revert to normal after bariatric surgery.

Objectives

To evaluate changes in the hypercoagulable state after bariatric surgery.

Setting

University Hospital, Bariatric Center of Excellence, United States.

Methods

Thromboelastography (TEG) data were collected on 72 subjects with morbid obesity, with 36 who had 6 months of follow-up after bariatric surgery. TEG data of 75

SUBMITTER: Samuels J 

PROVIDER: S-EPMC6719338 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature