Cortical cerebral blood flow in ageing: effects of haematocrit, sex, ethnicity and diabetes.

ABSTRACT:

Objectives

Cerebral blood flow (CBF) estimates from arterial spin labelling (ASL) show unexplained variability in older populations. We studied the impact of variation of haematocrit (Hct) on CBF estimates in a tri-ethnic elderly population.

Materials and methods

Approval for the study was obtained from the Fulham Research Ethics Committee and participants gave written informed consent. Pseudo-continuous arterial spin labelling was performed on 493 subjects (age 55-90) from a tri-ethnic community-based cohort recruited in London. CBF was estimated using a simplified Buxton equation, with and without correction for Hct measured from blood samples. Differences in perfusion were compared, stratified by sex, ethnicity and diabetes. Results of Student's t tests were reported with

SUBMITTER: Smith LA 

PROVIDER: S-EPMC6719435 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature