Intensity of exposure to pulmonary tuberculosis determines risk of tuberculosis infection and disease.

ABSTRACT: Household contacts of pulmonary tuberculosis (TB) patients are at increased risk of TB infection and disease. However, their risk in relation to the intensity of exposure remains unknown.We studied smear-positive TB cases and their household contacts in Vitória, Brazil. We collected clinical, demographic and radiographic information from TB cases, and obtained tuberculin skin test (TST) and QuantiFERON-TB Gold (QFT) results from household contacts. We measured intensity of exposure using a proximity score and sleep location in relation to the TB index case and defined infection by TST ≥10 mm or QFT ≥0.35 UI·mL^-1 We ascertained secondary TB cases by reviewing local and nationwide case registries.We included 160 TB index cases and 894 household contacts. 464 (65%) had TB infection

SUBMITTER: Acuna-Villaorduna C 

PROVIDER: S-EPMC6719538 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature