Urine Biomarkers to Predict Response to Lupus Nephritis Therapy in Children and Young Adults.

ABSTRACT:

Objective

To delineate urine biomarkers that forecast response to therapy of lupus nephritis (LN).

Methods

Starting from the time of kidney biopsy, patients with childhood-onset systemic lupus erythematosus who were diagnosed with LN were studied serially. Levels of 15 biomarkers were measured in random spot urine samples, including adiponectin, α-1-acid glycoprotein (AGP), ceruloplasmin, hemopexin, hepcidin, kidney injury molecule 1, monocyte chemotactic protein-1, lipocalin-like prostaglandin D synthase (LPGDS), transforming growth factor-β (TGF-β), transferrin, and vitamin D binding protein (VDBP).

Results

Among 87 patients (mean age 15.6 yrs) with LN, there were 37 treatment responders and 50 nonresponders based on the American College of Rheumatology criteria. At

SUBMITTER: Brunner HI 

PROVIDER: S-EPMC6719540 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature