Synergistic Interaction of HOXB13 and CIP2A Predisposes to Aggressive Prostate Cancer.

ABSTRACT:

Purpose

Distinguishing aggressive prostate cancer from indolent disease improves personalized treatment. Although only few genetic variants are known to predispose to aggressive prostate cancer, synergistic interactions of HOXB13 G84E high-risk prostate cancer susceptibility mutation with other genetic loci remain unknown. The purpose of this study was to examine the interplay of HOXB13 rs138213197 (G84E) and CIP2A rs2278911 (R229Q) germline variants on prostate cancer risk.

Experimental design

Genotyping was done in Finnish discovery cohort (n = 2,738) and validated in Swedish (n = 3,132) and independent Finnish (n = 1,155) prostate cancer cohorts. Expression pattern analysis was followed by functional studies in prostate cancer cel

SUBMITTER: Sipeky C 

PROVIDER: S-EPMC6719560 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature