Carvedilol Among Patients With Heart Failure With a Cocaine-Use Disorder.

ABSTRACT:

Objectives

This study sought to assess the safety of carvedilol therapy among heart failure (HF) patients with a cocaine-use disorder (CUD).

Background

Although carvedilol therapy is recommended among certain patients with HF, the safety and efficacy of carvedilol among HF patients with a CUD is unknown.

Methods

This was a single-center study of hospitalized patients with HF. Cocaine use was self-reported or defined as having a positive urine toxicology. Patients were divided by carvedilol prescription. Subgroup analyses were performed by strata of ejection fraction (EF) ≤40%, 41% to 49%, or ≥50%. Major adverse cardiovascular events (MACE) were defined as cardiovascular mortality and 30-day HF readmission.

Results

From a cohort of 2,578 patients hospitalized wi

SUBMITTER: Banerji D 

PROVIDER: S-EPMC6719721 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature