Interleukin-32 Contributes to Human Nonalcoholic Fatty Liver Disease and Insulin Resistance.

ABSTRACT: Nonalcoholic fatty liver disease (NAFLD) is a metabolic disorder due to increased accumulation of fat in the liver and in many cases to enhanced inflammation. Although the contribution of inflammation in the pathogenesis of NAFLD is well established, the cytokines that are involved and how they influence liver transformation are still poorly characterized. In addition, with other modifiers, inflammation influences NAFLD progression to liver cirrhosis and hepatocellular carcinoma, demonstrating the need to find new molecular targets with potential future therapeutic applications. We investigated gene signatures in 38 liver biopsies from patients with NAFLD and obesity who had received bariatric surgery and compared these to 10 control patients who had received a cholecystectomy, using DNA m

SUBMITTER: Dali-Youcef N 

PROVIDER: S-EPMC6719754 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature