Dose-dependent association of accelerometer-measured physical activity and sedentary time with brain perfusion in aging.

ABSTRACT:

Introduction

Age-related decreases in cerebral blood flow (CBF) may lead to cognitive decline, while physical activity (PA) can maintain CBF and cognition in aging. The intensity of PA needed to affect CBF in aging, and the independent effects of sedentary time on CBF are currently unknown. Moreover, research conducted in free-living environments with objective measures of PA (e.g., accelerometry) is lacking.

Methods

This cross-sectional study used accelerometry to objectively measure sedentary time, all light PA [AllLightPA], moderate-to-vigorous PA [MVPA], and total activity counts [TAC] in 52 cognitively healthy older adults. Robust linear regressions investigated the association of CBF (using arterial spin labeling magnetic resonance imaging) in frontal and medial tempor

SUBMITTER: Zlatar ZZ 

PROVIDER: S-EPMC6719795 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature