Strategies for Predicting Response to Checkpoint Inhibitors.

ABSTRACT:

Purpose of review

Despite the clinical successes of immune checkpoint blockade across multiple tumor types, many patients do not respond to these therapies or become resistant after an initial response. This underscores the need to improve our understanding of the molecular determinants of response to guide more personalized and rational utilization of these therapies. Here, we describe available biomarkers of checkpoint blockade activity by classifying them into four major categories: tumor-intrinsic, immune microenvironmental, host-related, and dynamic factors.

Recent findings

The clinical experience accumulated thus far with checkpoint blockade now offers the opportunity to comprehensively study the molecular and immune features associated with response. This is yielding

SUBMITTER: Zappasodi R 

PROVIDER: S-EPMC6719799 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature