Engineered action at a distance: Blood-meal-inducible paralysis in Aedes aegypti.

ABSTRACT:

Background

Population suppression through mass-release of Aedes aegypti males carrying dominant-lethal transgenes has been demonstrated in the field. Where population dynamics show negative density-dependence, suppression can be enhanced if lethality occurs after the density-dependent (i.e. larval) stage. Existing molecular tools have limited current examples of such Genetic Pest Management (GPM) systems to achieving this through engineering 'cell-autonomous effectors' i.e. where the expressed deleterious protein is restricted to the cells in which it is expressed-usually under the control of the regulatory elements (e.g. promoter regions) used to build the system. This limits the flexibility of these technologies as regulatory regions with useful spatial, temporal or sex-specific

SUBMITTER: Haghighat-Khah RE 

PROVIDER: S-EPMC6719823 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature