Deciphering GRINA/Lifeguard1: Nuclear Location, Ca²⁺ Homeostasis and Vesicle Transport.

ABSTRACT: The Glutamate Receptor Ionotropic NMDA-Associated Protein 1 (GRINA) belongs to the Lifeguard family and is involved in calcium homeostasis, which governs key processes, such as cell survival or the release of neurotransmitters. GRINA is mainly associated with membranes of the endoplasmic reticulum, Golgi, endosome, and the cell surface, but its presence in the nucleus has not been explained yet. Here we dissect, with the help of different software tools, the potential roles of GRINA in the cell and how they may be altered in diseases, such as schizophrenia or celiac disease. We describe for the first time that the cytoplasmic N-terminal half of GRINA (which spans a Proline-rich domain) contains a potential DNA-binding sequence, in addition to cleavage target sites and probable PY-nuclear l

SUBMITTER: Jimenez-Gonzalez V 

PROVIDER: S-EPMC6719933 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature