Potential for Tight Junction Protein-Directed Drug Development Using Claudin Binders and Angubindin-1.

ABSTRACT: The tight junction (TJ) is an intercellular sealing component found in epithelial and endothelial tissues that regulates the passage of solutes across the paracellular space. Research examining the biology of TJs has revealed that they are complex biochemical structures constructed from a range of proteins including claudins, occludin, tricellulin, angulins and junctional adhesion molecules. The transient disruption of the barrier function of TJs to open the paracellular space is one means of enhancing mucosal and transdermal drug absorption and to deliver drugs across the blood-brain barrier. However, the disruption of TJs can also open the paracellular space to harmful xenobiotics and pathogens. To address this issue, the strategies targeting TJ proteins have been developed to loosen TJs

SUBMITTER: Hashimoto Y 

PROVIDER: S-EPMC6719960 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature