Clinical correlation of influenza and respiratory syncytial virus load measured by digital PCR.

ABSTRACT: Acute respiratory tract infections are a major cause of respiratory morbidity and mortality in pediatric patients worldwide. However, accurate viral and immunologic markers to predict clinical outcomes of this patient population are still lacking. Droplet digital PCR assays for influenza and respiratory syncytial virus (RSV) were designed and performed in 64 respiratory samples from 23 patients with influenza virus infection and 73 samples from 19 patients with RSV infection. Samples of patients with hematologic malignancies, solid tumors, or sickle cell disease were included. Clinical information from institutional medical records was reviewed to assess disease severity. Samples from patients with fever or respiratory symptoms had a significantly higher viral loads than those from asympto

SUBMITTER: Hijano DR 

PROVIDER: S-EPMC6720028 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature