Transcriptome analyses of tumor-adjacent somatic tissues reveal genes co-expressed with transposable elements.

ABSTRACT:

Background

Despite the long-held assumption that transposons are normally only expressed in the germ-line, recent evidence shows that transcripts of transposable element (TE) sequences are frequently found in the somatic cells. However, the extent of variation in TE transcript levels across different tissues and different individuals are unknown, and the co-expression between TEs and host gene mRNAs have not been examined.

Results

Here we report the variation in TE derived transcript levels across tissues and between individuals observed in the non-tumorous tissues collected for The Cancer Genome Atlas. We found core TE co-expression modules consisting mainly of transposons, showing correlated expression across broad classes of TEs. Despite this co-expression within tissues,

SUBMITTER: Chung N 

PROVIDER: S-EPMC6720085 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature