Analyzing the regulation of miRNAs on protein-protein interaction network in Hodgkin lymphoma.

ABSTRACT:

Background

Hodgkin Lymphoma (HL) is a type of aggressive malignancy in lymphoma that has high incidence in young adults and elderly patients. Identification of reliable diagnostic markers and efficient therapeutic targets are especially important for the diagnosis and treatment of HL. Although many HL-related molecules have been identified, our understanding on the molecular mechanisms underlying the disease is still far from complete due to its complex and heterogeneous characteristics. In such situation, exploring the molecular mechanisms underlying HL via systems biology approaches provides a promising option. In this study, we try to elucidate the molecular mechanisms related to the disease and identify potential pharmaceutical targets from a network-based perspective.

Resul

SUBMITTER: Lei H 

PROVIDER: S-EPMC6720096 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature