Carcinogenic effect of potassium octatitanate (POT) fibers in the lung and pleura of male Fischer 344 rats after intrapulmonary administration.

ABSTRACT:

Background

Potassium octatitanate fibers (K₂O•8TiO₂, POT fibers) are used as an asbestos substitute. Their physical characteristics suggest that respirable POT fibers are likely to be carcinogenic in the lung and pleura. However, previous 2-year inhalation studies reported that respired POT fibers had little or no carcinogenic potential. In the present study ten-week old male F344 rats were left untreated or were administered vehicle, 0.25 or 0.5 mg rutile-type nano TiO₂ (r-nTiO₂), 0.25 or 0.5 mg POT fibers, or 0.5 mg MWCNT-7 by intra-tracheal intra-pulmonary spraying (TIPS), and then observed for 2 years.

Results

There were no differences between the r-nTiO₂ and control groups. The incidence of bronchiolo-alveolar cell

SUBMITTER: Abdelgied M 

PROVIDER: S-EPMC6720102 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature