Effects of oxycodone on brain responses to emotional images.

ABSTRACT:

Rationale

Evidence from animal and human studies suggests that opiate drugs decrease emotional responses to negative stimuli and increase responses to positive stimuli. Such emotional effects may motivate misuse of oxycodone (OXY), a widely abused opiate. Yet, we know little about how OXY affects neural circuits underlying emotional processing in humans.

Objective

We examined effects of OXY on brain activity during presentation of positive and negative visual emotional stimuli. We predicted that OXY would decrease amygdala activity to negative stimuli and increase ventral striatum (VS) activity to positive stimuli. Secondarily, we examined the effects of OXY on other emotional network regions on an exploratory basis.

Methods

In a three-session study, healthy adults (N

SUBMITTER: Wardle MC 

PROVIDER: S-EPMC6720110 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature