Gout and the risk of advanced chronic kidney disease in the UK health system: a national cohort study.

ABSTRACT:

Objective

Evaluate the association between gout and risk of advanced chronic kidney disease (CKD).

Design

Retrospective matched cohort study.

Setting

UK Clinical Practice Research Datalink.

Participants

The analysis included data for 68 897 patients with gout and 554 964 matched patients without gout. Patients were aged ≥18 years, registered at UK practices, had ≥12 months of clinical data and had data linked with Hospital Episode Statistics. Patients were excluded for history of advanced CKD, juvenile gout, cancer, HIV, tumour lysis syndrome, Lesch-Nyhan syndrome or familial Mediterranean fever.

Primary and secondary outcome measures

Advanced CKD was defined as first occurrence of: (1) dialysis, kidney transplant, diagnosis of end-stage kidney disease (

SUBMITTER: Stack AG 

PROVIDER: S-EPMC6720233 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature