Lyn regulates epithelial-mesenchymal transition in CS-exposed model through Smad2/3 signaling.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation that is progressive and not fully reversible. Cigarette smoking is one of the most commonly and important risk factors for COPD, which contributes to airway remodeling, the outstanding pathological changes in COPD. One potential mechanism which might be important for airway remodeling is the process called epithelial-mesenchymal transition (EMT). However, the underlying molecular mechanisms of EMT in CS-induced COPD are still poorly understood.

Methods

Two Gene Expression Omnibus (GEO) datasets (GSE108134 and GSE5058) were combined to identify the key genes involved in COPD. Then, single-gene analysis of Lyn was performed. Lyn expression was confirmed in patients with COPD. 16HBE c

SUBMITTER: Liang X 

PROVIDER: S-EPMC6720409 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature