Doxorubicin-loaded human serum albumin nanoparticles overcome transporter-mediated drug resistance in drug-adapted cancer cells.

ABSTRACT: Resistance to systemic drug therapy is a major reason for the failure of anticancer therapies. Here, we tested doxorubicin-loaded human serum albumin (HSA) nanoparticles in the neuroblastoma cell line UKF-NB-3 and its ABCB1-expressing sublines adapted to vincristine (UKF-NB-3^rVCR¹) and doxorubicin (UKF-NB-3^rDOX²⁰). Doxorubicin-loaded nanoparticles displayed increased anticancer activity in UKF-NB-3^rVCR¹ and UKF-NB-3^rDOX²⁰ cells relative to doxorubicin solution, but not in UKF-NB-3 cells. UKF-NB-3^rVCR¹ cells were re-sensitised by nanoparticle-encapsulated doxorubicin to the level of UKF-NB-3 cells. UKF-NB-3^rDOX²⁰ cells displayed a more pronounced resistance phe

SUBMITTER: Onafuye H 

PROVIDER: S-EPMC6720578 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature