Transfer of a Multiclass Method for over 60 Antibiotics in Food from High Resolution to Low Resolution Mass Spectrometry.

ABSTRACT: A multiclass method has been developed to screen and confirm a wide range of anti-microbial residues in muscle and milk, and validated using liquid-chromatography coupled to (low-resolution, LR) tandem mass spectrometry (LC-QqQ). Over sixty antibiotics, belonging to ten distinct families, were included in the method scope. The development process was rapidly concluded as a result of two previously implemented methods. This consisted of identical sample treatments, followed by liquid chromatography, and coupled with high-resolution (HR) mass spectrometry (LC-Q-Orbitrap). The validation study was performed in the range between 10-1500 μg·kg-1 for muscles and 2-333 μg·kg-1 for milk. The main performance characteristics were estimated and, then, compared to those previously obtained with HR te

SUBMITTER: Giusepponi D 

PROVIDER: S-EPMC6720601 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature