Consistent Biomarkers and Related Pathogenesis Underlying Asthma Revealed by Systems Biology Approach.

ABSTRACT: Asthma is a common chronic airway disease worldwide. Due to its clinical and genetic heterogeneity, the cellular and molecular processes in asthma are highly complex and relatively unknown. To discover novel biomarkers and the molecular mechanisms underlying asthma, several studies have been conducted by focusing on gene expression patterns in epithelium through microarray analysis. However, few robust specific biomarkers were identified and some inconsistent results were observed. Therefore, it is imperative to conduct a robust analysis to solve these problems. Herein, an integrated gene expression analysis of ten independent, publicly available microarray data of bronchial epithelial cells from 348 asthmatic patients and 208 healthy controls was performed. As a result, 78 up- and 75 down

SUBMITTER: Nie X 

PROVIDER: S-EPMC6720652 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature