Carnosine Decreases PMA-Induced Oxidative Stress and Inflammation in Murine Macrophages.

ABSTRACT: Carnosine is an endogenous dipeptide composed of β-alanine and L-histidine. This naturally occurring molecule is present at high concentrations in several mammalian excitable tissues such as muscles and brain, while it can be found at low concentrations in a few invertebrates. Carnosine has been shown to be involved in different cellular defense mechanisms including the inhibition of protein cross-linking, reactive oxygen and nitrogen species detoxification as well as the counteraction of inflammation. As a part of the immune response, macrophages are the primary cell type that is activated. These cells play a crucial role in many diseases associated with oxidative stress and inflammation, including atherosclerosis, diabetes, and neurodegenerative diseases. In the present study, carnosine

SUBMITTER: Caruso G 

PROVIDER: S-EPMC6720685 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature