SigsPack, a package for cancer mutational signatures.

ABSTRACT:

Background

Mutational signatures are specific patterns of somatic mutations introduced into the genome by oncogenic processes. Several mutational signatures have been identified and quantified from multiple cancer studies, and some of them have been linked to known oncogenic processes. Identification of the processes contributing to mutations observed in a sample is potentially informative to understand the cancer etiology.

Results

We present here SigsPack, a Bioconductor package to estimate a sample's exposure to mutational processes described by a set of mutational signatures. The package also provides functions to estimate stability of these exposures, using bootstrapping. The performance of exposure and exposure stability estimations have been validated using synthetic a

SUBMITTER: Schumann F 

PROVIDER: S-EPMC6720940 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature