TREM2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding.

ABSTRACT:

Background

Adipose tissue remodeling plays a significant role in obesity-induced insulin resistance. Published studies reported that level of trigger receptor expressed on myeloid cells 2 (TREM2) in adipose tissue is up-regulated in animal models of obesity. This study aims to investigate whether TREM2 regulates obesity-induced insulin resistance via modulating adipose tissue remodeling in mice of high-fat diet (HFD).

Methods

Wild-type (WT) and TREM2^-/- mice were both fed with a controlled-fat diet (CFD) or HFD for 12 weeks and studied for obesity and insulin resistance. Meanwhile, epididymal adipose tissue (EAT) was examined for morphological and pathological changes to determine adipose tissue remodeling. After that, adipocyte-derived MCP-1 was measured in adipo

SUBMITTER: Liu C 

PROVIDER: S-EPMC6720981 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature