Genomics and the Acute Respiratory Distress Syndrome: Current and Future Directions.

ABSTRACT: The excessive hospital mortality associated with acute respiratory distress syndrome (ARDS) in adults mandates an urgent need for developing new therapies and tools for the early risk assessment of these patients. ARDS is a heterogeneous syndrome with multiple different pathogenetic processes contributing differently in different patients depending on clinical as well as genetic factors. Identifying genetic-based biomarkers holds the promise for establishing effective predictive and prognostic stratification methods and for targeting new therapies to improve ARDS outcomes. Here we provide an updated review of the available evidence supporting the presence of genetic factors that are predictive of ARDS development and of fatal outcomes in adult critically ill patients and that have been ide

SUBMITTER: Hernandez-Beeftink T 

PROVIDER: S-EPMC6721149 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature