Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease results from a neurodegenerative process that starts well before the diagnosis can be made. New prognostic or diagnostic markers enabling early intervention into the disease process would be highly valuable. Environmental and lifestyle factors largely modulate the disease risk and may influence the pathogenesis through epigenetic mechanisms, such as DNA methylation. As environmental and lifestyle factors may affect multiple tissues of the body, we hypothesized that the disease-associated DNA methylation signatures are detectable in the peripheral blood of discordant twin pairs.

Results

Comparison of 23 disease discordant Finnish twin pairs with reduced representation bisulfite sequencing revealed peripheral blood DNA methylation differences in

SUBMITTER: Konki M 

PROVIDER: S-EPMC6721173 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature