Immunotherapy in Hodgkin Lymphoma: Present Status and Future Strategies.

ABSTRACT: Although classical Hodgkin lymphoma (cHL) is usually curable, 20-30% of the patients experience treatment failure and most of them are typically treated with salvage chemotherapy and autologous stem cell transplantation (autoSCT). However, 45-55% of that subset further relapse or progress despite intensive treatment. At the advanced stage of the disease course, recently developed immunotherapeutic approaches have provided very promising results with prolonged remissions or disease stabilization in many patients. Brentuximab vedotin (BV) has been approved for patients with relapsed/refractory cHL (rr-cHL) who have failed autoSCT, as a consolidation after autoSCT in high-risk patients, as well as for patients who are ineligible for autoSCT or multiagent chemotherapy who have failed ≥ two tre

SUBMITTER: Vassilakopoulos TP 

PROVIDER: S-EPMC6721364 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature