Anoctamin 3: A Possible Link between Cluster Headache and Ca2+ Signaling.

ABSTRACT: Cluster headache is a severe primary headache characterized by extremely painful attacks of unilateral headache. Verapamil is commonly used as a prophylactic treatment with good effect. In order to search for new pathways involved in the pathophysiology of cluster headache, we analyzed genetic variants that were previously linked to verapamil response in migraine in a Swedish cluster headache case-control sample. We used TaqMan qPCR for genetic screening and performed a gene expression analysis on associated genes in patient-derived fibroblasts, and further investigated which reference genes were suitable for analysis in fibroblasts from cluster headache patients. We discovered a significant association between anoctamin3, a gene encoding a calcium-activated ion channel, and cluster headac

SUBMITTER: Ran C 

PROVIDER: S-EPMC6721385 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature