Novel Apoptosis-Inducing Agents for the Treatment of Cancer, a New Arsenal in the Toolbox.

ABSTRACT: : Evasion from apoptosis is an important hallmark of cancer cells. Alterations of apoptosis pathways are especially critical as they confer resistance to conventional anti-cancer therapeutics, e.g., chemotherapy, radiotherapy, and targeted therapeutics. Thus, successful induction of apoptosis using novel therapeutics may be a key strategy for preventing recurrence and metastasis. Inhibitors of anti-apoptotic molecules and enhancers of pro-apoptotic molecules are being actively developed for hematologic malignancies and solid tumors in particular over the last decade. However, due to the complicated apoptosis process caused by a multifaceted connection with cross-talk pathways, protein-protein interaction, and diverse resistance mechanisms, drug development within the category has be

SUBMITTER: Lim B 

PROVIDER: S-EPMC6721450 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature