Association of CREBRF variants with obesity and diabetes in Pacific Islanders from Guam and Saipan.

ABSTRACT:

Aims/hypothesis

Variants in CREBRF (rs12513649 and rs373863828) have been strongly associated with increased BMI and decreased risk of type 2 diabetes in Polynesian populations; the A allele at rs373863828 is common in Polynesians but rare in most other global populations. The aim of the present study was to assess the association of CREBRF variants with obesity and diabetes in Pacific Islander (largely Marianas and Micronesian) populations from Guam and Saipan.

Methods

CREBRF rs12513649 and rs373863828 were genotyped in 2022 participants in a community-based cross-sectional study designed to identify determinants of diabetes and end-stage renal disease (ESRD). Associations were analysed with adjustment for age, sex, ESRD and the first four genetic principal components from

SUBMITTER: Hanson RL 

PROVIDER: S-EPMC6721609 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature