Epigenetic Changes as a Target in Aging Haematopoietic Stem Cells and Age-Related Malignancies.

ABSTRACT: Aging is associated with multiple molecular and functional changes in haematopoietic cells. Most notably, the self-renewal and differentiation potential of hematopoietic stem cells (HSCs) are compromised, resulting in myeloid skewing, reduced output of red blood cells and decreased generation of immune cells. These changes result in anaemia, increased susceptibility for infections and higher prevalence of haematopoietic malignancies. In HSCs, age-associated global epigenetic changes have been identified. These epigenetic alterations in aged HSCs can occur randomly (epigenetic drift) or are the result of somatic mutations in genes encoding for epigenetic proteins. Mutations in loci that encode epigenetic modifiers occur frequently in patients with haematological malignancies, but also in he

SUBMITTER: Buisman SC 

PROVIDER: S-EPMC6721661 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature