N-Acetylcysteine Serves as Substrate of 3-Mercaptopyruvate Sulfurtransferase and Stimulates Sulfide Metabolism in Colon Cancer Cells.

ABSTRACT: Hydrogen sulfide (H₂S) is an endogenously produced signaling molecule. The enzymes 3-mercaptopyruvate sulfurtransferase (MST), partly localized in mitochondria, and the inner mitochondrial membrane-associated sulfide:quinone oxidoreductase (SQR), besides being respectively involved in the synthesis and catabolism of H₂S, generate sulfane sulfur species such as persulfides and polysulfides, currently recognized as mediating some of the H₂S biological effects. Reprogramming of H₂S metabolism was reported to support cellular proliferation and energy metabolism in cancer cells. As oxidative stress is a cancer hallmark and N-acetylcysteine (NAC) was recently suggested to act as an antioxidant by increasing intracellular levels of sulfane sulfur

SUBMITTER: Zuhra K 

PROVIDER: S-EPMC6721681 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature