Structural basis of NKT cell inhibition using the T-cell receptor-blocking anti-CD1d antibody 1B1.

ABSTRACT: Natural killer T (NKT) cells are a subset of T lymphocytes that recognize glycolipid antigens presented by the CD1d molecule (CD1d). They rapidly respond to antigen challenge and can activate both innate and adaptive immune cells. To study the role of antigen presentation in NKT cell activation, previous studies have developed several anti-CD1d antibodies that block CD1d binding to T-cell receptors (TCRs). Antibodies that are specific to both CD1d and the presented antigen can only be used to study the function of only a limited number of antigens. In contrast, antibodies that bind CD1d and block TCR binding regardless of the presented antigen can be widely used to assess the role of TCR-mediated NKT cell activation in various disease models. Here, we report the crystal structure of the wi

SUBMITTER: Ying G 

PROVIDER: S-EPMC6721955 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature