Potentially repurposable drugs for schizophrenia identified from its interactome.

ABSTRACT: We previously presented the protein-protein interaction network of schizophrenia associated genes, and from it, the drug-protein interactome which showed the drugs that target any of the proteins in the interactome. Here, we studied these drugs further to identify whether any of them may potentially be repurposable for schizophrenia. In schizophrenia, gene expression has been described as a measurable aspect of the disease reflecting the action of risk genes. We studied each of the drugs from the interactome using the BaseSpace Correlation Engine, and shortlisted those that had a negative correlation with differential gene expression of schizophrenia. This analysis resulted in 12 drugs whose differential gene expression (drug versus normal) had an anti-correlation with differential express

SUBMITTER: Karunakaran KB 

PROVIDER: S-EPMC6722087 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature