Non-classical tissue monocytes and two functionally distinct populations of interstitial macrophages populate the mouse lung.

ABSTRACT: Resident tissue macrophages (RTM) can fulfill various tasks during development, homeostasis, inflammation and repair. In the lung, non-alveolar RTM, called interstitial macrophages (IM), importantly contribute to tissue homeostasis but remain little characterized. Here we show, using single-cell RNA-sequencing (scRNA-seq), two phenotypically distinct subpopulations of long-lived monocyte-derived IM, i.e. CD206⁺ and CD206^-IM, as well as a discrete population of extravasating CD64⁺CD16.2⁺ monocytes. CD206⁺ IM are peribronchial self-maintaining RTM that constitutively produce high levels of chemokines and immunosuppressive cytokines. Conversely, CD206^-IM preferentially populate the alveolar interstitium and exhibit features of

SUBMITTER: Schyns J 

PROVIDER: S-EPMC6722135 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature