Characterization of Long Noncoding RNA and mRNA Profiles in Sepsis-Induced Myocardial Depression.

ABSTRACT: Septic shock with heart dysfunction is very common in intensive care units. However, whether long noncoding RNA (lncRNA) and mRNA profiles differ between patients with and without myocardial depression is unknown. We generated rat models of hypodynamic septic shock induced by lipopolysaccharide. A total of 12 rat models was constructed and heart tissue from each was collected. Whole genomic RNA sequencing was performed on left ventricular tissue; 6,508 novel lncRNAs and 432 annotated lncRNAs were identified in heart samples, and 74 lncRNAs were expressed differently in the sepsis and control groups. Gene ontology term enrichment indicated apoptosis and its related pathways showed obvious enrichment, which suggested cell apoptosis could play a critical role in the process of myocardial depr

SUBMITTER: Zhang TN 

PROVIDER: S-EPMC6722300 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature