Unique epithelial expression of S100A calcium binding protein A7A in the endometrium at conceptus implantation in pigs

ABSTRACT:

Objective

S100A7A, a member of the S100 protein family, is involved in various biological processes, including innate immunity, antimicrobial function, and epithelial tumorigenesis. However, the expression and function of S100A7A in the endometrium during the estrous cycle and pregnancy are not well understood in pigs. Therefore, this study determined the expression and regulation of S100A7A at the maternal-conceptus interface in pigs.

Methods

We obtained endometrial tissues from pigs throughout the estrous cycle and pregnancy, conceptus tissues during early pregnancy, and chorioallantoic tissues during mid- to late pregnancy and analyzed the expression of S100A7A in these tissues. We also determined the effects of steroid hormones, estradiol-17β (E2) and progesterone, and i

SUBMITTER: Lee S 

PROVIDER: S-EPMC6722313 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature