Echocardiography Core Laboratory Reproducibility of Cardiac Safety Assessments in Cardio-Oncology.

ABSTRACT:

Background

As the potential for cancer therapy-related cardiac dysfunction is increasingly recognized, there is a need for the standardization of echocardiographic measurements and cut points to guide treatment. The aim of this study was to determine the reproducibility of cardiac safety assessments across two academic echocardiography core laboratories (ECLs) at the University of Pennsylvania and the Duke Clinical Research Institute.

Methods

To harmonize the application of guideline-recommended measurement conventions, the ECLs conducted multiple training sessions to align measurement practices for traditional and emerging assessments of left ventricular (LV) function. Subsequently, 25 echocardiograms taken from patients with breast cancer treated with doxorubicin with or w

SUBMITTER: Khouri MG 

PROVIDER: S-EPMC6722324 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature