Repression of TGF-β Signaling in Breast Cancer Cells by miR-302/367 Cluster.

ABSTRACT:

Objective

Epigenetic alterations of the malignantly transformed cells have increasingly been regarded as an important event in the carcinogenic development. Induction of some miRNAs such as miR-302/367 cluster has been shown to induce reprogramming of breast cancer cells and exert a tumor suppressive role by induction of mesenchymal to epithelial transition, apoptosis and a lower proliferation rate. Here, we aimed to investigate the impact of miR-302/367 overexpression on transforming growth factor-beta (TGF-β) signaling and how this may contribute to tumor suppressive effects of miR-302/367 cluster.

Materials and methods

In this experimental study, MDA-MB-231 and SK-BR-3 breast cancer cells were cultured and transfected with miR-302/367 expressing lentivector. The impact of

SUBMITTER: Ahmadalizadeh Khanehsar M 

PROVIDER: S-EPMC6722449 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature