Impact of PSCA gene polymorphisms in modulating gastric cancer risk in the Chinese population.

ABSTRACT: Previous studies have identified the prostate stem cell antigen (PSCA) gene rs2294008 C > T and rs2976392 G > A polymorphisms to be associated with the risk of gastric cancer, the results of which are inconsistent. The present study aimed to evaluate the association between the two polymorphisms and the gastric cancer risk in the Chinese population. A hospital-based case-control study was conducted on 549 cases and 592 healthy controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were applied to evaluate the association of the two polymorphisms on the gastric cancer risk. We found that both rs2294008 (CT vs. CC, OR = 1.55, 95% CI = 1.20-1.99, P<0.001 and CT+TT vs. CC, OR = 1.38, 95% CI = 1.09-1.74, P=0.008) and rs2976392 (GA vs. GG, OR = 1.61, 95% CI = 1.25-2.07, P<0.001 and GA+AA

SUBMITTER: Yan K 

PROVIDER: S-EPMC6722488 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature