The Structural Versatility of the BTB Domains of KCTD Proteins and Their Recognition of the GABA_B Receptor.

ABSTRACT: Several recent investigations have demonstrated that members of the KCTD (Potassium Channel Tetramerization Domain) protein family are involved in fundamental processes. However, the paucity of structural data available on these proteins has frequently prevented the definition of their biochemical role(s). Fortunately, this scenario is rapidly changing as, in very recent years, several crystallographic structures have been reported. Although these investigations have provided very important insights into the function of KCTDs, they have also raised some puzzling issues. One is related to the observation that the BTB (broad-complex, tramtrack, and bric-à-brac) domain of these proteins presents a remarkable structural versatility, being able to adopt a variety of oligomeric states. To gain i

SUBMITTER: Balasco N 

PROVIDER: S-EPMC6722564 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature