Study of the Combination of Self-Activating Photodynamic Therapy and Chemotherapy for Cancer Treatment.

ABSTRACT: Cancer is a very challenging disease to treat, both in terms of treatment efficiency and side-effects. To overcome these problems, there have been extensive studies regarding the possibility of improving treatment by employing combination therapy, and by exploring therapeutic modalities with reduced side-effects (such as photodynamic therapy (PDT)). Herein, this work has two aims: (i) to develop self-activating photosensitizers for use in light-free photodynamic therapy, which would eliminate light-related restrictions that this therapy currently possesses; (ii) to assess their co-treatment potential when combined with reference chemotherapeutic agents (Tamoxifen and Metformin). We synthesized three new photosensitizers capable of self-activation and singlet oxygen production via a chemilu

SUBMITTER: Pinto da Silva L 

PROVIDER: S-EPMC6722738 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature