Nutritional Risk Factors, Microbiota and Parkinson's Disease: What Is the Current Evidence?

ABSTRACT: Parkinson's disease (PD) is a frequent neurodegenerative disease among elderly people. Genetic and underlying environmental factors seem to be involved in the pathogenesis of PD related to degeneration of dopaminergic neurons in the striatum. In previous experimental researches oxidative stress, mitochondrial dysfunction, homocysteine, and neuroinflammation have been reported as potential mechanisms. Among environmental factors, nutrition is one of the most investigated areas as it is a potentially modifiable factor. The purpose of this review is to provide current knowledge regarding the relation between diet and PD risk. We performed a comprehensive review including the most relevant studies from the year 2000 onwards including prospective studies, nested case-control studies, and meta-a

SUBMITTER: Boulos C 

PROVIDER: S-EPMC6722832 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature