DNA Methylation Module Network-Based Prognosis and Molecular Typing of Cancer.

ABSTRACT: Achieving cancer prognosis and molecular typing is critical for cancer treatment. Previous studies have identified some gene signatures for the prognosis and typing of cancer based on gene expression data. Some studies have shown that DNA methylation is associated with cancer development, progression, and metastasis. In addition, DNA methylation data are more stable than gene expression data in cancer prognosis. Therefore, in this work, we focused on DNA methylation data. Some prior researches have shown that gene modules are more reliable in cancer prognosis than are gene signatures and that gene modules are not isolated. However, few studies have considered cross-talk among the gene modules, which may allow some important gene modules for cancer to be overlooked. Therefore, we constructe

SUBMITTER: Cui ZJ 

PROVIDER: S-EPMC6722866 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature