Chromosomics: Bridging the Gap between Genomes and Chromosomes.

ABSTRACT: The recent advances in DNA sequencing technology are enabling a rapid increase in the number of genomes being sequenced. However, many fundamental questions in genome biology remain unanswered, because sequence data alone is unable to provide insight into how the genome is organised into chromosomes, the position and interaction of those chromosomes in the cell, and how chromosomes and their interactions with each other change in response to environmental stimuli or over time. The intimate relationship between DNA sequence and chromosome structure and function highlights the need to integrate genomic and cytogenetic data to more comprehensively understand the role genome architecture plays in genome plasticity. We propose adoption of the term 'chromosomics' as an approach encompassing geno

SUBMITTER: Deakin JE 

PROVIDER: S-EPMC6723020 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature