Gene Expression Patterns Unveil New Insights in Papillary Thyroid Cancer.

ABSTRACT: Background and objectives: Papillary thyroid carcinoma is the most frequent variety of all malignant endocrine tumors. It represents a heterogeneous malignancy with various clinical outcomes, emphasizing the need to identify powerful biomarkers with clinical relevance. Materialsand Methods: Available gene expression data (level 3) for thyroid cancers were downloaded from the Cancer Genome Atlas (TCGA), followed by bioinformatic analyses performed on the data set. Results: Based on gene expression analysis, we were able to identify common and specific gene signatures for the three main types of papillary thyroid carcinoma (classical, follicular variant, and tall-cell). The survival rate was not significantly different among the main subtypes, but we were able to identify a biological adhesi

SUBMITTER: Saftencu M 

PROVIDER: S-EPMC6723230 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature